Division of Clinical Nutrition, Department of Food and Nutrition, Japan Women's University, Tokyo, Japan.
Nutrition. 2012 Nov-Dec;28(11-12):1109-14. doi: 10.1016/j.nut.2012.02.009.
We assessed whether disease activity was associated with dietary habits, nutritional status, adipokines, and oxidative stress in patients with rheumatoid arthritis.
The subjects were 37 patients with RA. The assessment of the nutritional status included anthropometric and biochemical parameters. A food-frequency questionnaire and a 3-d diet record to assess dietary intake were used. The serum levels of adipokines and oxidative stress markers in sera and saliva were measured. The disease activity was determined using the 28 Disease Activity Score (DAS28). We divided the subjects into high (DAS28 ≥3.2) and low (DAS28 <3.2) disease activity groups.
The serum leptin and albumin levels were significantly lower, whereas the inflammatory markers were increased, in the high disease activity group. The dietary intake assessment showed a lower intake of fish oil and a lower ratio of monounsaturated fatty acid intake in the high disease activity group. There was a negative correlation between the DAS28 and the dietary intake of the ratio of monounsaturated fatty acid to total fatty acid intake. The serum oxidative stress marker (reactive oxygen metabolites) showed a positive correlation to the DAS28. The salivary reactive oxygen metabolites also correlated with C-reactive protein and serum reactive oxygen metabolites.
Altered serum adipokine levels with decreased albumin may reflect the deterioration that is associated with rheumatoid arthritis. An increased oxidative stress was observed in sera and saliva. Intakes of ω-3 polyunsaturated fatty acids, fish oil, and monounsaturated fatty acid seem to affect disease activity and may have beneficial effects by decreasing inflammation.
我们评估了类风湿关节炎患者的疾病活动度是否与饮食习惯、营养状况、脂肪因子和氧化应激有关。
研究对象为 37 例类风湿关节炎患者。营养状况评估包括人体测量学和生化参数。使用食物频率问卷和 3 天饮食记录来评估饮食摄入。测量血清和唾液中脂肪因子和氧化应激标志物的水平。采用 28 关节疾病活动度评分（DAS28）评估疾病活动度。我们将患者分为高（DAS28≥3.2）和低（DAS28<3.2）疾病活动组。
高疾病活动组血清瘦素和白蛋白水平较低，而炎症标志物升高。饮食摄入评估显示高疾病活动组摄入的鱼油和单不饱和脂肪酸摄入比例较低。DAS28 与单不饱和脂肪酸与总脂肪酸摄入比例的饮食摄入呈负相关。血清氧化应激标志物（活性氧代谢物）与 DAS28 呈正相关。唾液中的活性氧代谢物与 C 反应蛋白和血清活性氧代谢物也相关。
血清脂肪因子水平降低伴白蛋白减少可能反映了与类风湿关节炎相关的病情恶化。在血清和唾液中观察到氧化应激增加。ω-3 多不饱和脂肪酸、鱼油和单不饱和脂肪酸的摄入似乎会影响疾病活动度，并通过减轻炎症产生有益影响。
