School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, China.
Bioorg Med Chem Lett. 2012 Nov 15;22(22):6862-6. doi: 10.1016/j.bmcl.2012.09.038. Epub 2012 Sep 20.
Two benzophenone glucopyranosides have been isolated from the nut shell part of Mahkota Dewa. The structures were identified as 2,4',6-trihydroxy-4-methoxy-benzophenone-2-O-β-d-glucoside (Mahkoside A) and 2,4',6-trihydroxy-4-methoxy-6″-acetyl-benzophenone-2-O-β-d-glucoside (Mahkoside B). Mahkoside B was recognized as a novel compound. Furthermore, a series of benzophenone glucopyranoside derivatives (compounds 3-18) were synthesized and their bioactivities were characterized. Our results demonstrated that compound 18 has significant cytotoxicity against two esophageal cancer cell lines, stomach cancer cell line and prostate cancer cell line, with IC(50) less than 10 μM, indicating its potential activity against cancer cells.
从大花紫薇坚果壳部分分离得到两个苯甲酮葡萄糖苷。结构鉴定为 2,4',6-三羟基-4-甲氧基苯甲酮-2-O-β-d-葡萄糖苷（Mahkoside A）和 2,4',6-三羟基-4-甲氧基-6″-乙酰基苯甲酮-2-O-β-d-葡萄糖苷（Mahkoside B）。Mahkoside B 被确认为一种新化合物。此外，还合成了一系列苯甲酮葡萄糖苷衍生物（化合物 3-18），并对其生物活性进行了表征。我们的研究结果表明，化合物 18 对两种食管癌细胞系、胃癌细胞系和前列腺癌细胞系具有显著的细胞毒性，IC50 小于 10 μM，表明其对癌细胞具有潜在的活性。
