Li Chuang-Jun, Xie Fu-Gui, Yang Jing-Zhi, Luo Yong-Ming, Chen Xiao-Guang, Zhang Dong-Ming
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2012;14(10):973-80. doi: 10.1080/10286020.2012.729049.
Two new sesquiterpene pyridine alkaloids hypoglaunines E (1) and F (2) and a new triterpenoid saponin hypoglaside A (3), together with a known diterpenoid glucoside11-O-β-D-glucopyranosyl neotriptophenolide (4) and two known triterpenoids 23-noroxopristimerol(5) and 2,3-dihydroxy-6-oxo-D:A-froedo-24 nor-1,3,5(10),7-oleanatetraen-29-oic acid (6), have been isolated from the root barks of Tripterygiumhypoglaucum. Their structures were elucidated by NMR spectroscopy and MS analysis.Compounds 1–3 were screened for their cytotoxic activities against five cancer celllines, but all of them were inactive.
从昆明山海棠的根皮中分离得到两个新的倍半萜吡啶生物碱昆明山海棠碱E（1）和F（2）、一个新的三萜皂苷昆明山海棠苷A（3），以及一个已知的二萜糖苷11-O-β-D-吡喃葡萄糖基新雷公藤内酯醇（4）和两个已知的三萜类化合物23-降氧化表木栓醇（5）和2,3-二羟基-6-氧代-D:A-弗罗多-24-降-1,3,5(10),7-齐墩果烷四烯-29-酸（6）。通过核磁共振光谱和质谱分析对它们的结构进行了阐明。对化合物1-3针对五种癌细胞系的细胞毒性活性进行了筛选，但它们均无活性。
