Department of Psychiatry, University College of Medical Sciences & G.T.B.Hospital, Delhi 110095, India.
Asian J Psychiatr. 2011 Sep;4(3):178-82. doi: 10.1016/j.ajp.2011.05.008. Epub 2011 Aug 25.
Obsessive Compulsive Disorder (OCD) is one of most frequently diagnosed psychiatric illness, tends to run a chronic course and severely affects the patient's quality of life (QoL). The aim of this study was to assess QoL in patients with OCD and compare it with QoL of patients with major depressive disorder (MDD) and healthy controls. Forty-five patients with OCD, fifty patients with the diagnosis of MDD and one hundred and fifty healthy controls were evaluated using WHOQoL-BREF, Hindi version and their QoL scores were compared. Symptom severity of the OCD group was measured using Yale Brown Obsessive Compulsive Scale (YBOCS) and was charted longitudinally over a period of 6 months. The QoL of patients with OCD was found to be significantly lower in the domains of physical, psychological well-being and social domains as compared to the healthy controls. When compared with patients with MDD, the pre-treatment QoL of patients with OCD was found to be significantly higher. Six months follow up found Psychological health domains of QoL better in the MDD group than the OCD group. Between MDD and OCD groups, statistically significant differences were noted in the environment domains, though overall improvement in QoL scores was noted in both the groups in all domains. YBOCS scores significantly improved with treatment in OCD patients, as did the scores on WHOQoL-BREF. Minimal correlation was found between changes in YBOCS scores and QoL scores in OCD subjects at 6 months follow up. These findings indicate that all aspects of QoL are markedly affected in individuals with OCD, QoL scores improve with treatment and the changes in QoL scores over a period of 6 months are not necessarily correlated with corresponding changes in YBOCS scores (indicative of symptom severity in OCD subjects).
强迫症（OCD）是最常见的精神疾病之一，往往呈慢性病程，严重影响患者的生活质量（QoL）。本研究旨在评估 OCD 患者的 QoL，并将其与重度抑郁症（MDD）患者和健康对照者进行比较。采用 WHOQoL-BREF、印地语版对 45 例 OCD 患者、50 例 MDD 患者和 150 例健康对照者进行评估，并比较其 QoL 评分。采用耶鲁布朗强迫症量表（YBOCS）对 OCD 组的症状严重程度进行测量，并在 6 个月内进行纵向记录。与健康对照组相比，OCD 组患者的生理、心理和社会领域的 QoL 明显较低。与 MDD 患者相比，OCD 患者的治疗前 QoL 明显较高。6 个月随访发现，MDD 组的心理健康领域 QoL 优于 OCD 组。在 MDD 和 OCD 组之间，环境领域的差异具有统计学意义，尽管两组在所有领域的 QoL 评分都有所提高。OCD 患者的 YBOCS 评分随治疗显著改善，WHOQoL-BREF 评分也显著改善。在 6 个月随访时，OCD 患者的 YBOCS 评分变化与 QoL 评分之间仅发现最小的相关性。这些发现表明，OCD 患者的所有 QoL 方面都受到明显影响，QoL 评分随治疗而改善，并且在 6 个月内 QoL 评分的变化不一定与 YBOCS 评分的相应变化相关（提示 OCD 患者的症状严重程度）。
