Cornick N A, Silva M, Gorbach S L
Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.
Rev Infect Dis. 1990 Jan-Feb;12 Suppl 1:S9-10. doi: 10.1093/clinids/12.supplement_1.s9.
This study was undertaken to determine the in vitro activity of bismuth subsalicylate (BSS) and sodium salicylate (SS) against various groups of pathogenic bacteria. BSS had the greatest activity against Clostridium difficile, which had a minimal inhibitory concentration for 90% of the strains (MIC90) of 128 micrograms/mL. The Bacteroides fragilis group also had a relatively low MIC90 of 512 micrograms/mL. BSS had the least activity against Pseudomonas (MIC90, 6,144 micrograms/mL). SS was as active as BSS against aerobic bacteria but was less active against anaerobic bacteria. The MIC90 values of SS for C. difficile and the B. fragilis group were greater than 8,192 and 4,096 micrograms/mL, respectively. This study demonstrates that BSS has antibacterial activity in vitro at levels that should be achievable in the gastrointestinal tract.
本研究旨在确定次水杨酸铋（BSS）和水杨酸钠（SS）对各类病原菌的体外活性。BSS对艰难梭菌的活性最强，其对90%菌株的最低抑菌浓度（MIC90）为128微克/毫升。脆弱拟杆菌属的MIC90也相对较低，为512微克/毫升。BSS对铜绿假单胞菌的活性最低（MIC90为6144微克/毫升）。SS对需氧菌的活性与BSS相当，但对厌氧菌的活性较低。SS对艰难梭菌和脆弱拟杆菌属的MIC90值分别大于8192微克/毫升和4096微克/毫升。本研究表明，BSS在体外具有抗菌活性，且在胃肠道中应能达到相应水平。
