Föhr P, Hautmann V, Prodinger P, Pohlig F, Kaddick C, Burgkart R
Abteilung für Biomechanik, Klinik für Orthopädie und Sportorthopädie , Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.
Orthopade. 2012 Oct;41(10):820-6. doi: 10.1007/s00132-012-1953-4.
Articular cartilage repair methods, in particular scaffold-based autologous chondrocyte implantation, are already in clinical use. In the coming years, the European guidelines on human cell-based medicinal products by the European Medical Agency (EMA) will extend today's quality control mechanisms by additional structural analyses. As articular cartilage has complex biphasic and viscoelastic mechanical properties, a high-performance material test system is required and has already been implemented. To characterize the recovery of cartilage and cartilage replacement materials, it is necessary to measure the dynamic recovery profile. A measurement system for an application like this requires an axis acceleration of more then 50 m/s(2). Furthermore, the test system needs custom-made components to fix the biological specimen while testing. A software package consisting of a graphical user interface and an axis controller leads to highly reproducible tests. The software makes use of a position and velocity controller as well as a force controller at kilohertz speed. While using the high performance force controller it is possible to apply static and dynamic loading profiles that are independent from position or speed set points and signals.
关节软骨修复方法，特别是基于支架的自体软骨细胞移植，已在临床中应用。在未来几年，欧洲药品管理局（EMA）关于人源细胞医药产品的欧洲指南将通过额外的结构分析扩展当今的质量控制机制。由于关节软骨具有复杂的双相和粘弹性力学性能，因此需要并已经实施了高性能材料测试系统。为了表征软骨和软骨替代材料的恢复情况，有必要测量动态恢复曲线。像这样的应用测量系统需要超过50 m/s²的轴向加速度。此外，测试系统需要定制组件来在测试时固定生物样本。由图形用户界面和轴控制器组成的软件包可实现高度可重复的测试。该软件利用位置和速度控制器以及千赫兹速度的力控制器。在使用高性能力控制器时，可以应用独立于位置或速度设定点和信号的静态和动态加载曲线。
