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[关节软骨的摩擦学评估。一种用于分析软骨、再生组织和组织工程构建体摩擦系数的系统;初步结果]

[Tribological assessment of articular cartilage. A system for the analysis of the friction coefficient of cartilage, regenerates and tissue engineering constructs; initial results].

作者信息

Schwarz M L R, Schneider-Wald B, Krase A, Richter W, Reisig G, Kreinest M, Heute S, Pott P P, Brade J, Schütte A

机构信息

Sektion experimentelle Orthopädie und Unfallchirurgie, Orthopädisch-Unfallchirurgisches Zentrum, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

出版信息

Orthopade. 2012 Oct;41(10):827-36. doi: 10.1007/s00132-012-1951-6.

DOI:10.1007/s00132-012-1951-6
PMID:23052849
Abstract

Values for the friction coefficient of articular cartilage are given in ranges of percentage and lower and are calculated as a quotient of the friction force and the perpendicular loading force acting on it. Thus, a sophisticated system has to be provided for analysing the friction coefficient under different conditions in particular when cartilage should be coupled as friction partner. It is possible to deep-freeze articular cartilage before measuring the friction coefficient as the procedure has no influence on the results. The presented tribological system was able to distinguish between altered and native cartilage. Furthermore, tissue engineered constructs for cartilage repair were differentiated from native cartilage probes by their friction coefficient. In conclusion a tribological equipment is presented to analyze the friction coefficient of articular cartilage, in vivo generated cartilage regenerates and in vitro tissue engineered constructs regarding their biomechanical properties for quality assessment.

摘要

关节软骨摩擦系数的值以百分比范围及更低的形式给出,并通过摩擦力与作用于其上的垂直加载力的商来计算。因此,必须提供一个复杂的系统来分析不同条件下的摩擦系数,特别是当软骨作为摩擦伙伴耦合时。在测量摩擦系数之前对关节软骨进行深度冷冻是可行的,因为该过程对结果没有影响。所展示的摩擦学系统能够区分改变的软骨和天然软骨。此外,用于软骨修复的组织工程构建体通过其摩擦系数与天然软骨探针区分开来。总之,展示了一种摩擦学设备,用于分析关节软骨、体内生成的软骨再生组织和体外组织工程构建体的摩擦系数,以评估它们的生物力学性能。

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引用本文的文献

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Resilience to height loss of articular cartilage of osteoarthritic stifle joints of old pigs, compared with healthy cartilage from young pigs in a tribological pin-on-plate exposure, revealing similar friction forces.在摩擦学销钉盘试验中,与来自年轻猪的健康软骨相比,老猪患骨关节炎的膝关节软骨高度降低的弹性,显示出相似的摩擦力。
PLoS One. 2021 Apr 23;16(4):e0250244. doi: 10.1371/journal.pone.0250244. eCollection 2021.
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本文引用的文献

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The effect of contact stress on cartilage friction, deformation and wear.接触应力对软骨摩擦、变形及磨损的影响。
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Experimental friction coefficients for bovine cartilage measured with a pin-on-disk tribometer: testing configuration and lubricant effects.用销盘式摩擦试验机测量牛软骨的实验摩擦系数:测试配置和润滑剂的影响。
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J Orthop Surg Res. 2015 Jul 28;10:117. doi: 10.1186/s13018-015-0257-x.
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[Defect models for the regeneration of articular cartilage in large animals].[大型动物关节软骨再生的缺损模型]
Orthopade. 2013 Apr;42(4):242-53. doi: 10.1007/s00132-012-2044-2.
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Orthopade. 2013 Apr;42(4):232-41. doi: 10.1007/s00132-013-2074-4.
兔膝关节实验性血关节后生物摩擦学和生物力学的变化。
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Analysis of frictional behavior and changes in morphology resulting from cartilage articulation with porous polyurethane foams.分析软骨关节与多孔聚氨酯泡沫的摩擦行为和形态变化。
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Liposomes act as effective biolubricants for friction reduction in human synovial joints.脂质体在减少人体滑膜关节摩擦中作为有效的生物润滑剂发挥作用。
Langmuir. 2010 Jan 19;26(2):1107-16. doi: 10.1021/la9024712.
6
Influence of dynamic load on friction behavior of human articular cartilage, stainless steel and polyvinyl alcohol hydrogel as artificial cartilage.动态载荷对人工关节软骨中关节软骨、不锈钢和聚乙烯醇水凝胶的摩擦行为的影响。
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The effect of sliding velocity on chondrocytes activity in 3D scaffolds.
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An equine joint friction test model using a cartilage-on-cartilage arrangement.一种采用软骨对软骨排列的马关节摩擦测试模型。
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Effect of nominal stress on the long term friction, deformation and wear of native and glycosaminoglycan deficient articular cartilage.名义应力对天然和缺乏糖胺聚糖的关节软骨的长期摩擦、变形及磨损的影响
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Association between friction and wear in diarthrodial joints lacking lubricin.缺乏润滑素的动关节中摩擦与磨损之间的关联。
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