Kollmar R, Gebhardt B, Schwab S
Klinik für Neurologie und Neurogeriatrie, Klinikum Darmstadt, Grafenstr. 9, 64283 Darmstadt, Deutschland.
Nervenarzt. 2012 Oct;83(10):1252-9. doi: 10.1007/s00115-012-3533-6.
Therapeutic hypothermia (TH) improves the neurological outcome in experimental brain trauma models as well as in patients suffering from cardiac arrest and perinatal asphyxia. So far the efficacy of TH has not been proven in acute ischemic stroke due to lack of clinical data. The EuroHYP-1 study will investigate whether TH with an individual target range temperature between 34 and 35 °C administered for 24 h will improve the neurological outcome in ischemic stroke patients treated within 6 h from symptom onset. The target patient number of 1,500 to be included in EuroHYP-1 is sufficiently powered to detect the efficacy of TH.
治疗性低温（TH）可改善实验性脑创伤模型以及心脏骤停和围产期窒息患者的神经学预后。迄今为止，由于缺乏临床数据，TH在急性缺血性卒中中的疗效尚未得到证实。欧洲低温治疗研究1（EuroHYP-1）将调查，对症状发作6小时内接受治疗的缺血性卒中患者给予24小时的个体化目标体温范围在34至35摄氏度之间的TH，是否会改善其神经学预后。纳入EuroHYP-1的目标患者数量为1500例，足以检测TH的疗效。
