Schellinger P D, Köhrmann M, Röther J
Neurologische Klinik und Neurogeriatrie, Johannes Wesling Klinikum Minden, Hans-Nolte-Str. 1, 32429 Minden, Deutschland.
Nervenarzt. 2012 Oct;83(10):1260-9. doi: 10.1007/s00115-012-3534-5.
Several acute stroke trials are underway or have been recently completed. Among the latter are the ICTUS trial and the IST-3 trial. Several other approaches are being tested for thrombolytic therapy among them modern imaging-based patient selection and new thrombolytic agents, such as desmoteplase and tenecteplase. Other strategies include neuroprotection and neurorestoration, biophysical approaches, such as near infrared laser therapy, hemodynamic augmentation and sphenopalatine ganglion stimulation. Mechanical thrombectomy is practiced in many centers although randomized trials are pending and the IMS-3 trial was stopped. This overview will cover the very recently completed and currently recruiting acute ischemic stroke trials.
多项急性中风试验正在进行中或最近已经完成。后者包括ICTUS试验和IST - 3试验。其他几种溶栓治疗方法也正在进行测试，其中包括基于现代成像的患者选择以及新型溶栓药物，如去氨普酶和替奈普酶。其他策略包括神经保护和神经修复、生物物理方法，如近红外激光治疗、血流动力学增强和蝶腭神经节刺激。尽管随机试验尚未进行且IMS - 3试验已停止，但许多中心仍在开展机械取栓术。本综述将涵盖最近完成的以及目前正在招募患者的急性缺血性中风试验。
