Hyotan-machi ENT Clinic, Hyotan-machi 2-13, Kanazawa 920-0845, Japan.
Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1335-8. doi: 10.1007/s00405-012-2203-4. Epub 2012 Oct 5.
Physiological investigation of olfactory receptor function in hyposmic or anosmic patients is rare. Pioneers examined the electro-olfactogram in patients with olfactory disturbance. Although the electro-olfactogram is an established method to record olfactory responses from human olfactory epithelium, the response is only measured at specific sites of the olfactory mucosa. In contrast to that the response of the olfactory epithelium to chemosensory stimuli can be studied in a specific nasal area by means of intrinsic optical signal recording. Five functionally anosmic patients were included in the present study. In all patients, responses could be obtained following trigeminal stimulation with CO2. In some patients, responses could be obtained after olfactory stimulation with H2S and PEA. The present data show that in the studied patients trigeminal function seems to be preserved, while it appears that in some patients olfactory function is preserved to a certain degree.
嗅觉障碍患者嗅觉受体功能的生理学研究很少。先驱者检查了嗅觉障碍患者的嗅电图。虽然嗅电图是记录人嗅上皮嗅觉反应的一种既定方法，但反应仅在嗅黏膜的特定部位测量。与之相反，通过固有光学信号记录，可以研究嗅觉上皮对化学感觉刺激的反应在特定的鼻腔区域。本研究纳入了 5 名功能性嗅觉丧失患者。在所有患者中，经三叉神经刺激 CO2 后均能获得反应。在一些患者中，经 H2S 和 PEA 嗅觉刺激后也能获得反应。目前的数据表明，在所研究的患者中，三叉神经功能似乎得到保留，而在某些患者中，嗅觉功能在一定程度上得到保留。
