Kobal G, Hummel T
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Erlangen, Germany.
Laryngoscope. 1998 Jul;108(7):1033-5. doi: 10.1097/00005537-199807000-00015.
The aim of this study was to investigate the usefulness of chemosensory event-related potentials (CSERPs) in response to both olfactory and intranasal trigeminal stimulation in the diagnosis of anosmia. Forty-four patients participated. Gaseous CO2 was used for trigeminal stimulation, vanillin and H2S were used as olfactory stimulants. Event-related potentials to olfactory stimuli could not be obtained in any of the anosmic patients, indicating the complete loss of the sense of smell. However, all patients responded to stimulation of the trigeminal nerve with CO2. These data clearly demonstrate the clinical significance of CSERPs in the assessment of anosmia.
本研究的目的是探讨化学感觉事件相关电位（CSERPs）在嗅觉和鼻内三叉神经刺激反应中对嗅觉丧失诊断的有用性。44名患者参与了研究。使用气态二氧化碳进行三叉神经刺激，香草醛和硫化氢用作嗅觉刺激物。在任何嗅觉丧失患者中均未获得与嗅觉刺激相关的电位，表明嗅觉完全丧失。然而，所有患者对二氧化碳刺激三叉神经均有反应。这些数据清楚地证明了CSERPs在嗅觉丧失评估中的临床意义。
