Geraghty J J, Jankovic J, Zetusky W J
Ann Neurol. 1985 Apr;17(4):329-33. doi: 10.1002/ana.410170404.
To examine a possible relationship of essential tremor to Parkinson's disease (PD), 130 patients with essential tremor were studied. Twenty-five patients had both essential tremor and PD. These 25 patients were matched for age and duration of PD symptoms with 25 patients who had idiopathic PD. Bradykinesia, postural instability, and gait difficulty were more severe in the patients with idiopathic PD. Degree of tremor, rigidity, and functional disability did not differ in the two groups. The prevalence of PD in the population with essential tremor was 24 times greater than expected. This study suggests that some patients with essential tremor have a genetically increased risk for PD.
为研究特发性震颤与帕金森病（PD）之间可能的关系，对130例特发性震颤患者进行了研究。25例患者同时患有特发性震颤和帕金森病。将这25例患者与25例特发性帕金森病患者按年龄和帕金森病症状持续时间进行匹配。特发性帕金森病患者的运动迟缓、姿势不稳和步态困难更为严重。两组患者的震颤程度、僵硬程度和功能障碍无差异。特发性震颤人群中帕金森病的患病率比预期高24倍。这项研究表明，一些特发性震颤患者患帕金森病的遗传风险增加。
