抗菌浸渍导管在预防住院患者导管相关血流感染中的应用
Antimicrobial impregnated catheters in the prevention of catheter-related bloodstream infection in hospitalized patients.
作者信息
Wassil Sarah K, Crill Catherine M, Phelps Stephanie J
机构信息
Departments of Clinical Pharmacy ; Le Bonheur Children's Medical Center, Memphis, Tennessee ; Baptist Wolfson Children's Hospital, Jacksonville, Florida.
出版信息
J Pediatr Pharmacol Ther. 2007 Apr;12(2):77-90. doi: 10.5863/1551-6776-12.2.77.
Abstract
Catheter-related bloodstream infections have a significant impact on increasing health care costs and morbidity and mortality in hospitalized patients. Many technologies have been created in an attempt to decrease the incidence of catheter-related bloodstream infection. One of these is the impregnation of central venous catheters with antiseptics (e.g., chlorhexidine and silver sulfadiazine) or antibiotics (e.g., minocycline and rifampin). While studies evaluating the efficacy of impregnated catheters have been conducted, the data are limited and their use remains variable across institutions. This paper will discuss catheter-related factors that predispose patients to catheter-related bloodstream infection, the types of antimicrobial-impregnated catheters in use today, studies evaluating their efficacy, and common concerns associated with the use of these catheters. Issues related to the cost-effectiveness of impregnated catheters and future directions for the prevention of catheter-related bloodstream infection will also be presented.
摘要
导管相关血流感染对增加住院患者的医疗费用以及发病率和死亡率有重大影响。人们研发了许多技术以试图降低导管相关血流感染的发生率。其中之一是用防腐剂（如氯己定和磺胺嘧啶银）或抗生素（如米诺环素和利福平）浸渍中心静脉导管。虽然已经开展了评估浸渍导管疗效的研究，但数据有限，并且其使用在各机构间仍存在差异。本文将讨论使患者易发生导管相关血流感染的导管相关因素、目前使用的抗菌浸渍导管的类型、评估其疗效的研究以及与使用这些导管相关的常见问题。还将介绍与浸渍导管成本效益相关的问题以及预防导管相关血流感染的未来方向。
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