Department of Sciences for Woman and Child's Health, Anna Meyer Children's University Hospital Florence, University of Florence, Italy.
Int J Immunopathol Pharmacol. 2012 Jul-Sep;25(3):557-64. doi: 10.1177/039463201202500301.
Data regarding the use of interferon-gamma release assays (IGRAs) for tuberculosis diagnosis are accumulating. We systematically searched PubMed, EMBASE and Cochrane and performed pooled estimates of sensitivity and specificity of QuantiFERON-TB Gold In Tube (QFT-G-IT) and T-SPOT.TB compared to tuberculin skin test (TST). For studies assessing sensitivity, children had to have active tuberculosis. Specificity data were derived from children classified as non-infected. Eleven studies were included in the sensitivity analysis for TST, 10 for QFT-G-IT, and 9 for T-SPOT.TB. Eight studies were included in specificity analysis for TST, 8 for QFT-G-IT, and 7 for T-SPOT.TB. Pooled QFT-G-IT sensitivity was 0.79 (95% CI:0.70-0.89) pooled T-SPOT.TB sensitivity was 0.74 (95% CI:0.59-0.90) and pooled TST sensitivity was 0.82 (95% CI:0.72-0.93). Pooled QFT-G-IT and T-SPOT.TB specificities were 0.95 (95% CI:0.93- 0.97) and 0.96 (95% CI:0.93-1.00), respectively. Pooled TST specificity was significantly lower 0.83 (95% CI:0.74-0.92). IGRA performance in children showed no better sensitivity than TST, but higher specificity.
有关干扰素-γ释放检测（IGRAs）用于结核病诊断的数据正在不断增加。我们系统地检索了 PubMed、EMBASE 和 Cochrane，并对 QuantiFERON-TB Gold In Tube（QFT-G-IT）和 T-SPOT.TB 与结核菌素皮肤试验（TST）相比的敏感性和特异性进行了汇总估计。对于评估敏感性的研究，儿童必须患有活动性结核病。特异性数据来自被归类为未感染的儿童。TST 的敏感性分析纳入了 11 项研究，QFT-G-IT 为 10 项，T-SPOT.TB 为 9 项。TST 的特异性分析纳入了 8 项研究，QFT-G-IT 为 8 项，T-SPOT.TB 为 7 项。汇总的 QFT-G-IT 敏感性为 0.79（95%CI：0.70-0.89），汇总的 T-SPOT.TB 敏感性为 0.74（95%CI：0.59-0.90），汇总的 TST 敏感性为 0.82（95%CI：0.72-0.93）。汇总的 QFT-G-IT 和 T-SPOT.TB 特异性分别为 0.95（95%CI：0.93-0.97）和 0.96（95%CI：0.93-1.00），汇总的 TST 特异性明显较低，为 0.83（95%CI：0.74-0.92）。IGRA 在儿童中的表现并不比 TST 具有更高的敏感性，但特异性更高。
