Liu Qiu-Yue, Han Fen, Pan Li-Ping, Jia Hong-Yan, Li Qi, Zhang Zong-De
Department of Tuberculosis, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing 101149, P.R. China.
Intensive Care Unit, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing 101149, P.R. China.
Exp Ther Med. 2018 Mar;15(3):2719-2726. doi: 10.3892/etm.2018.5775. Epub 2018 Jan 19.
Pulmonary tuberculosis caused by remains a global problem. Inflammatory responses are the primary characteristics of patients with pulmonary tuberculosis in intensive care units (ICU). The aim of the present study was to investigate the clinical importance of inflammatory cells and factors for patients with pulmonary tuberculosis in ICU. A total of 124 patients with pulmonary tuberculosis in ICU were recruited for the present study. The inflammatory responses in patients with pulmonary tuberculosis in ICU were examined by changes in inflammatory cells and factors in the serum. The results indicated that serum levels of lymphocytes, plasma cells, granulocytes and monocytes were increased in patients with pulmonary tuberculosis in ICU compared with healthy controls. The serum levels of inflammatory factors interleukin (IL)-1, IL-6, IL-10, IL-12, and IL-4 were upregulated in patients with pulmonary tuberculosis in ICU. Lower plasma concentrations of IL-2, IL-15 and interferon-γ were detected in patients with pulmonary tuberculosis compared with healthy controls. It was demonstrated that high mobility group box-1 protein expression levels were higher in the serum of patients with pulmonary tuberculosis compared with healthy controls. Notably, an imbalance of T-helper cell (Th)1/Th2 cytokines was observed in patients with pulmonary tuberculosis. Pulmonary tuberculosis caused by also upregulated expression of matrix metalloproteinase (MMP)-1 and MMP-9 in hPMCs. In conclusion, these outcomes demonstrated that inflammatory responses and inflammatory factors are associated with the progression of pulmonary tuberculosis, suggesting that inhibition of inflammatory responses and inflammatory factors may be beneficial for the treatment of patients with pulmonary tuberculosis in ICU.
由……引起的肺结核仍然是一个全球性问题。炎症反应是重症监护病房（ICU）中肺结核患者的主要特征。本研究的目的是调查炎症细胞和因子对ICU中肺结核患者的临床重要性。本研究共招募了124例ICU中的肺结核患者。通过血清中炎症细胞和因子的变化来检测ICU中肺结核患者的炎症反应。结果表明，与健康对照组相比，ICU中肺结核患者血清中的淋巴细胞、浆细胞、粒细胞和单核细胞水平升高。ICU中肺结核患者血清中的炎症因子白细胞介素（IL）-1、IL-6、IL-10、IL-12和IL-4水平上调。与健康对照组相比，肺结核患者血浆中IL-2、IL-15和干扰素-γ的浓度较低。结果表明，与健康对照组相比，肺结核患者血清中高迁移率族蛋白盒1蛋白的表达水平更高。值得注意的是，在肺结核患者中观察到辅助性T细胞（Th）1/Th2细胞因子失衡。由……引起的肺结核还上调了人肺微血管内皮细胞（hPMCs）中基质金属蛋白酶（MMP）-1和MMP-9的表达。总之，这些结果表明炎症反应和炎症因子与肺结核的进展有关，提示抑制炎症反应和炎症因子可能有利于ICU中肺结核患者的治疗。
