Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa.
Planta Med. 2012 Nov;78(17):1857-60. doi: 10.1055/s-0032-1315386. Epub 2012 Oct 11.
Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 µM against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC50 values in the range of 4.30 to 94.32 µM against the chloroquine-sensitive D10 Plasmodium falciparum strain.
采用基于体外抗菌活性测定的活性导向分离方法，从 Ormocarpum trichocarpum 的地上部分分离得到五种双黄酮类化合物，其中两种为新化合物。分离得到的化合物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和肺炎克雷伯菌的 MIC 值范围为 4.0 至 136.7 μM，对氯喹敏感的 D10 恶性疟原虫株的 IC50 值范围为 4.30 至 94.32 μM。
