School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, Pietermaritzburg, South Africa.
Beilstein J Org Chem. 2013 Jul 8;9:1346-51. doi: 10.3762/bjoc.9.152. eCollection 2013.
The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental conditions for the oxidative cyclization to form ochnaflavone were established.
首次全合成了不对称二芳基醚双黄酮 ochnaflavone，它由芹菜素和木犀草素两部分组成，以及 2,3,2'',3''-四氢 ochnaflavone 的全甲基醚。ochnaflavone 合成的关键步骤是形成二芳基醚和环状缩合连接二聚查尔酮的醚环化，以组装两个黄酮核。建立了形成 ochnaflavone 的最佳氧化环化实验条件。
