DiMaio V J, Garriott J C
J Forensic Sci. 1977 Jan;22(1):152-8.
Propylhexedrine, a local vasoconstrictor, is the active ingredient in the Benzedrex nasal inhaler. In a six-month period, the Office of the Medical Examiner of Dallas County has encountered three deaths resulting from intravenous injection of propylhexedrine. Two of these individuals showed vascular changes in the lungs, apparently from chronic intravenous injections of this drug. Body distribution of the drug was determined in all of the cases by gas chromatographic analysis. An experiment was conducted to determine "therapeutic blood concentrations" in which a normal subject inhaled propylhexedrine from the Benzedrex inhaler. The maximum blood concentration was only 1/30 of the minimum concentration encountered in the reported cases.
丙己君，一种局部血管收缩剂，是苯齐德雷克斯鼻腔吸入器中的活性成分。在六个月的时间里，达拉斯县法医办公室遇到了三起因静脉注射丙己君而导致的死亡案例。其中两名死者肺部出现血管变化，显然是长期静脉注射这种药物所致。所有案例中的药物体内分布情况均通过气相色谱分析确定。进行了一项实验以测定“治疗血药浓度”，让一名正常受试者使用苯齐德雷克斯吸入器吸入丙己君。最高血药浓度仅为报告案例中所遇最低浓度的1/30。
