Mancusi-Ungaro H R, Decker W J, Forshan V R, Blackwell S J, Lewis S R
J Toxicol Clin Toxicol. 1983;21(3):359-72. doi: 10.3109/15563658308990427.
Propylhexedrine, the active ingredient in Benzedrex Inhalers, is extracted from the wicks of the inhalers by drug abusers for intravenous injection to provide a "desirable high." Six representative cases treated over a one-year period are presented to exemplify the potential for soft tissue injury. Because the actual constituents of the injected material prepared from the inhalers were not established, solutions were prepared from Benzedrex Inhalers according to the formula provided by one of the patients. The extract was then subjected to vigorous qualitative and quantitative analyses; the presence of essentially pure propylhexedrine hydrochloride was confirmed in varying concentrations. To examine the progression of injury following injection of the prepared extract, the ears of 12 New Zealand white rabbits were injected either intra-arterially or subcutaneously. The opposite ear of each rabbit served as a control. Both clinical and pathologic observations demonstrated injury consistent with intense local vasoconstriction. Injury did not appear to relate to impurities in the solution or other embolic phenomena. Finally, the laboratory findings are discussed with regard to the clinical examples. In sum, the insult to tissue from intravascular or local injection with propylhexedrine appears to respond, although poorly, to efforts to reverse the intense pharmacologic vasoconstriction.
丙己君是苯齐德吸入器中的活性成分，吸毒者会从吸入器的灯芯中提取该成分用于静脉注射，以获得“愉悦的快感”。本文呈现了在一年时间内治疗的6个典型案例，以例证软组织损伤的可能性。由于从吸入器制备的注射材料的实际成分尚未确定，根据一名患者提供的配方从苯齐德吸入器中制备了溶液。然后对提取物进行了严格的定性和定量分析；证实存在不同浓度的基本纯的盐酸丙己君。为了研究注射制备好的提取物后的损伤进展情况，对12只新西兰白兔的耳朵进行了动脉内或皮下注射。每只兔子的对侧耳朵作为对照。临床和病理观察均显示损伤与强烈的局部血管收缩一致。损伤似乎与溶液中的杂质或其他栓塞现象无关。最后，结合临床实例对实验室检查结果进行了讨论。总之，血管内或局部注射丙己君对组织造成的损伤，尽管效果不佳，但似乎对逆转强烈的药物性血管收缩的努力有反应。
