Chang Ai-Mei, Chen Chen-Chih
International Program in Animal Vaccine Technology, International College, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Research Center for Animal Biologics, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Pathogens. 2021 May 29;10(6):671. doi: 10.3390/pathogens10060671.
(CPPV-1) is a DNA virus causing gastrointestinal disease and immunosuppression in various terrestrial carnivores. Domestic dogs and cats are considered the primary CPPV-1 reservoirs. The habitat overlap of wild carnivores and free-roaming dogs increases the threat of CPPV-1 transmission between them. This study explored the CPPV-1 distribution among wild carnivores in Taiwan through PCR screening and compared the partial capsid protein (VP2) gene sequences from wild and domestic carnivores. In total, 181 samples were collected from 32 masked palm civets (), 63 Chinese ferret badgers (), and 86 crab-eating mongooses (), from 2015 to 2019 were screened for CPPV-1. The average prevalence of CPPV-1 was 17.7% (32/181), with the highest prevalence in masked palm civets (37.5%). In addition, a masked palm civet was coinfected with two CPPV-1 strains. Among the 33 partial VP2 gene sequences, 23 were identical to the sequences amplified from domestic dogs and cats in Asia, and the remaining 10 were identified for the first time. This study supported the circulation of CPPV-1 strains with the same genomic features as domestic carnivores that are also in wild carnivores from the same environment in Taiwan by molecular data. Therefore, further population control and health management of free-roaming domestic carnivores are recommended.
犬细小病毒1型（CPPV-1）是一种DNA病毒，可导致多种陆生食肉动物出现胃肠道疾病和免疫抑制。家犬和家猫被认为是CPPV-1的主要宿主。野生食肉动物与流浪狗的栖息地重叠增加了它们之间传播CPPV-1的威胁。本研究通过PCR筛查探索了台湾野生食肉动物中CPPV-1的分布情况，并比较了野生和家养食肉动物的部分衣壳蛋白（VP2）基因序列。2015年至2019年期间，共从32只椰子狸、63只鼬獾和86只食蟹獴身上采集了181份样本，对其进行CPPV-1筛查。CPPV-1的平均患病率为17.7%（32/181），其中椰子狸的患病率最高（37.5%）。此外，一只椰子狸同时感染了两种CPPV-1毒株。在33条部分VP2基因序列中，有23条与从亚洲家犬和家猫中扩增出的序列相同，其余10条为首次鉴定。本研究通过分子数据支持了与家养食肉动物具有相同基因组特征的CPPV-1毒株在台湾同一环境中的野生食肉动物中也存在传播。因此，建议对流浪家养食肉动物进一步进行种群控制和健康管理。
