Torres G, Lytle L D
Department of Psychology, University of California, Santa Barbara.
J Neural Transm Gen Sect. 1990;80(1):67-77. doi: 10.1007/BF01245023.
To determine whether extra-retinal mechanisms mediate photoperiodic changes in neonatal rat pineal gland N-acetyltransferase activity, 4-day-old intact or bilateral orbital enucleated rats were killed during the dark phase of the lighting cycle, either in darkness or following 4 hr exposure to fluorescent light. Light suppressed the high nighttime N-acetyltransferase activity equally in intact and enucleated pups. Subsequent studies showed that at least 0.5 hr exposure and nocturnal illuminances of 109 microW/cm2 or greater were required to cause statistically significant reductions in the activity of the enzyme in 4-day-old rats. Taken together, these data indicate that relatively intense environmental light can affect neonatal rat pineal gland biochemistry via extraretinal mechanisms.
为了确定视网膜外机制是否介导新生大鼠松果体N - 乙酰转移酶活性的光周期变化，在光照周期的黑暗阶段，处死4日龄完整或双侧眼眶摘除的大鼠，处死环境要么是黑暗，要么是在暴露于荧光灯下4小时之后。光照对完整和摘除眼球的幼鼠夜间较高的N - 乙酰转移酶活性的抑制作用相同。随后的研究表明，4日龄大鼠至少需要暴露0.5小时以及夜间光照强度达到109微瓦/平方厘米或更高，才能使该酶的活性出现统计学上的显著降低。综合这些数据表明，相对强烈的环境光可通过视网膜外机制影响新生大鼠松果体的生物化学。
