Torres G, Lytle L D
Department of Psychology, University of California, Santa Barbara.
J Pineal Res. 1989;7(3):211-20. doi: 10.1111/j.1600-079x.1989.tb00445.x.
Nocturnal light-induced changes in pineal gland N-acetyltransferase activity were investigated in intact or enucleated 4-, 6-, or 8-day-old maternally isolated rats maintained at different ambient temperatures. Nighttime enzyme activity was increased markedly in rats maintained in 23 degrees C compared to 35 degrees C environments. Four hours of nocturnal light significantly reduced N-acetyltransferase activity in intact rats at all ages studied when the animals were maintained at 35 degrees C. Shorter duration (1 min) nocturnal light reduced N-acetyltransferase activity in intact rats 6 days of age. However, the enzyme activity suppression observed after the 4 hr of nocturnal light was still present in 4-day-old rats (but not older animals) even when the younger animals had been made blind by bilateral orbital enucleation. Taken together, these data suggest that an extraretinal mechanism may mediate light-induced changes in some aspects of pineal gland indoleamine biochemistry in newborn rats.
在完整或摘除眼球的4日龄、6日龄或8日龄母婴分离大鼠中，研究了不同环境温度下夜间光照诱导的松果体N - 乙酰转移酶活性变化。与35℃环境相比，处于23℃环境中的大鼠夜间酶活性显著增加。当动物饲养在35℃时，4小时夜间光照显著降低了所有研究年龄的完整大鼠的N - 乙酰转移酶活性。较短时长（1分钟）的夜间光照降低了6日龄完整大鼠的N - 乙酰转移酶活性。然而，即使较年幼的动物已通过双侧眼眶摘除眼球致盲，4日龄大鼠（而非年长动物）在4小时夜间光照后仍出现酶活性抑制。综合来看，这些数据表明，视网膜外机制可能介导新生大鼠松果体吲哚胺生物化学某些方面的光诱导变化。
