Vogel R, Crick R P, Newson R B, Shipley M, Blackmore H, Bulpitt C J
Clinical Research Department, Merck Sharp & Dohme Research Laboratories, West Point, Pa.
Br J Ophthalmol. 1990 Jan;74(1):3-6. doi: 10.1136/bjo.74.1.3.
This paper reports the analyses on data from 747 patients with chronic simple glaucoma (CSG) recorded in the King's College Hospital glaucoma data base between January 1970 and February 1985, having a mean follow-up time of 5.1 years (mode 8 years) with the object of determining the relationship of intraocular pressure (IOP) and visual field loss in CSG. A highly significant negative relationship was found between the presenting visual field coefficient (FC) and the untreated IOP (r = -0.26, p = 0.0001) - that is, the higher the IOP on detection, the worse is the visual field. A weak negative correlation was present between the change of FC per year and the treated IOP (r = -0.06), p = less than 0.05). At treated IOPs less than or equal to 18 mmHg visual field loss averaged 0.6 unit per year and for IOPs greater than 18 mmHg the average loss was 1.2 units per year. The data confirm both the importance of a raised IOP in the causation of chronic glaucomatous visual field loss and the importance of reducing the IOP in patients with chronic simple glaucoma.
本文报告了对1970年1月至1985年2月间录入国王学院医院青光眼数据库的747例慢性单纯性青光眼（CSG）患者数据的分析，平均随访时间为5.1年（众数为8年），目的是确定慢性单纯性青光眼患者的眼压（IOP）与视野缺损之间的关系。研究发现，初始视野系数（FC）与未经治疗的眼压之间存在高度显著的负相关（r = -0.26，p = 0.0001）——也就是说，检测时眼压越高，视野越差。每年FC的变化与治疗后的眼压之间存在微弱的负相关（r = -0.06，p < 0.05）。当治疗后的眼压小于或等于18 mmHg时，视野缺损平均每年为0.6个单位；当眼压大于18 mmHg时，平均每年的缺损为1.2个单位。这些数据证实了眼压升高在慢性青光眼性视野缺损病因中的重要性，以及降低慢性单纯性青光眼患者眼压的重要性。
