Lüke Jan Niklas, Lüke Vincent, Dietlein Thomas, Wiedemann Johanna, Lappas Alexandra
Department of Ophthalmology, Medical Faculty and University Hospital of Cologne, Cologne, 50937, Germany.
Clin Ophthalmol. 2025 Sep 5;19:3227-3235. doi: 10.2147/OPTH.S534745. eCollection 2025.
To investigate the efficacy of MINIject (suprachoroidal stent) in lowering intraocular pressure (IOP) in eyes following failed filtering glaucoma surgery.
In this single-center retrospective study, 18 patients who had undergone suprachoroidal stent implantation after failed filtering surgery were analyzed. Follow-up was at least 12 months, and surgical success was measured by 12-month postoperative intraocular pressure (IOP), glaucoma medication, and revision surgery (criteria A: IOP < 21 mmHg, IOP reduction >20%, no revision surgery; criteria B: IOP < 18 mmHg, IOP reduction >20%, no revision surgery; criteria C: IOP ≤ 15 mmHg, IOP reduction ≥40%, no repeat surgery).
After a follow-up period of 12 months, the mean IOP decreased from 27.11±5.65 mmHg to 15.94±9.56 mmHg (p<0.01). The median 12-month postoperative IOP was 14.0 mmHg (IQR: 10.0-20.0 mmHg). The probability of surgical success was 66.66% for criteria A and B and 50% for criteria C. The identical success rates for criteria A and B were due to overlapping responder groups in this limited sample. Topical medication was significantly reduced from 4.06±1.08 to 2.13±1.36 (p<0.0001).
Supraciliary stent implantation provided an effective and safe treatment option for advanced glaucoma following failed filtering surgery and demonstrated significant intraocular pressure reduction. However, the small sample size limits the generalizability of these findings.
探讨MINIject(脉络膜上腔支架)降低青光眼滤过手术失败后患眼眼压(IOP)的疗效。
在这项单中心回顾性研究中,分析了18例滤过手术失败后接受脉络膜上腔支架植入术的患者。随访时间至少为12个月,手术成功的衡量标准为术后12个月的眼压(IOP)、青光眼药物治疗情况及翻修手术情况(标准A:眼压<21 mmHg,眼压降低>20%,无需翻修手术;标准B:眼压<18 mmHg,眼压降低>20%,无需翻修手术;标准C:眼压≤15 mmHg,眼压降低≥40%,无需再次手术)。
随访12个月后,平均眼压从27.11±5.65 mmHg降至15.94±9.56 mmHg(p<0.01)。术后12个月眼压中位数为14.0 mmHg(四分位间距:10.0 - 20.0 mmHg)。标准A和B的手术成功率为66.66%,标准C的手术成功率为50%。标准A和B的成功率相同是由于该有限样本中反应者组存在重叠。局部用药从4.06±1.08显著减少至2.13±1.36(p<0.0001)。
睫状体上腔支架植入为滤过手术失败后的晚期青光眼提供了一种有效且安全的治疗选择,并显示出显著的眼压降低效果。然而,样本量小限制了这些研究结果的普遍性。