Section of Endocrinology, Andrology and Internal Medicine, Department of Medical and Paediatric Sciences, University of Catania, Policlinico 'G. Rodolico', Catania 95123, Italy.
Asian J Androl. 2012 Nov;14(6):879-83. doi: 10.1038/aja.2012.49. Epub 2012 Oct 15.
No studies have evaluated the ultrasound features of the male sex accessory glands in infertile patients with bacterial male accessory gland infection (MAGI) according to the microbiological outcomes of bacterial cultures (absent, partial or complete) following antibiotic therapy administration. Therefore, the aim of this study was to evaluate the ultrasound characteristics of the prostate, seminal vesicles, and epididymal tracts after treatment with levofloxacin (a common quinolone antibiotic), in patients with infections caused by Escherichia coli (a Gram-negative bacterium) according to the Naber's classification, which includes the following categories: eradication, eradication with superinfection, persistence and persistence with superinfection. The study was conducted in 100 patients aged 25±8 years (range: 20-40 years) with bacterial MAGI and bacterial cultures positive only for E. coli (colony forming units ≥10(6) per ml). Retrospective analysis was conducted only on patients treated with oral levofloxacin (500 mg) administered once daily for 28 days who were recruited over the last 5 years. Following antibiotic treatment, patients with microbiological persistence or persistence with superinfection had a significantly higher percentage of ultrasound abnormalities suggestive of prostato-vesiculitis (PV) (30.2% and 36.0%, respectively) or prostato-vesiculo-epididymitis (PVE) (60.2% and 70.0%, respectively) compared with patients with microbiological eradication (PV=10.2% and PVE=8.2%, respectively) or eradication with superinfection (PV=18.8% and PVE=21.2%, respectively). In conclusion, patients with microbiological persistence or persistence plus superinfection showed the highest prevalence of complicated forms of MAGI (PV and PVE), compared with patients with microbiological eradication or eradication with superinfection.
尚无研究根据抗生素治疗后细菌培养的微生物学结果（不存在、部分或完全）评估细菌性男性附属性腺感染（MAGI）的不育患者的男性附属性腺的超声特征。因此，本研究旨在评估左氧氟沙星（一种常用的喹诺酮类抗生素）治疗后根据 Naber 分类（包括以下类别：消除、消除伴再感染、持续存在和持续伴再感染）的大肠杆菌（革兰氏阴性菌）感染患者的前列腺、精囊和附睾管的超声特征。该研究纳入了 100 名年龄 25±8 岁（20-40 岁）的细菌性 MAGI 患者，且细菌培养仅对大肠杆菌呈阳性（每毫升菌落形成单位≥10(6)）。仅对过去 5 年期间接受过单次口服 500mg 左氧氟沙星治疗（每日一次，共 28 天）的患者进行了回顾性分析。抗生素治疗后，微生物学持续存在或持续伴再感染的患者，超声异常提示前列腺-精囊炎（PV）（分别为 30.2%和 36.0%）或前列腺-精囊-附睾炎（PVE）（分别为 60.2%和 70.0%）的比例显著高于微生物学消除的患者（PV=10.2%和 PVE=8.2%）或消除伴再感染的患者（PV=18.8%和 PVE=21.2%）。总之，与微生物学消除或消除伴再感染的患者相比，微生物学持续存在或持续伴再感染的患者表现出 MAGI 最常见的复杂形式（PV 和 PVE）的发生率最高。
