Institute of Genetics and Animal Breeding in Jastrzębiec, Polish Academy of Sciences, 05-552, Magdalenka, Poland.
Mol Biol Rep. 2012 Dec;39(12):10957-70. doi: 10.1007/s11033-012-1997-x. Epub 2012 Oct 14.
Cathelicidins are small, cationic, antimicrobial peptides found in humans and other species, including farm animals (cattle, horses, pigs, sheep, goats, chickens, rabbits and in some species of fish). These proteolytically activated peptides are part of the innate immune system of many vertebrates. These peptides show a broad spectrum of antimicrobial activity against bacteria, enveloped viruses and fungi. Apart from exerting direct antimicrobial effects, cathelicidins can also trigger specific defense responses in the host. Their roles in various pathophysiological conditions have been studied in mice and humans, but there are limited information about their expression sites and activities in livestock. The aim of the present review is to summarize current information about these antimicrobial peptides in farm animals, highlighting peptide expression sites, activities, and future applications for human and veterinary medicine.
抗菌肽是存在于人类和其他物种（包括家畜（牛、马、猪、绵羊、山羊、鸡、兔和一些鱼类））中的小的、阳离子的、抗微生物肽。这些蛋白水解激活的肽是许多脊椎动物先天免疫系统的一部分。这些肽对细菌、包膜病毒和真菌表现出广谱的抗微生物活性。除了发挥直接的抗微生物作用外，抗菌肽还可以在宿主中引发特定的防御反应。它们在小鼠和人类的各种病理生理条件下的作用已在研究中，但关于它们在家畜中的表达部位和活性的信息有限。本综述的目的是总结关于家畜中这些抗菌肽的最新信息，突出肽的表达部位、活性以及在人类和兽医医学中的未来应用。
