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基因副本通过异位重组实现功能分化。

Functional divergence of gene duplicates through ectopic recombination.

机构信息

Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 22, B-3001 Leuven (Heverlee), Belgium.

出版信息

EMBO Rep. 2012 Dec;13(12):1145-51. doi: 10.1038/embor.2012.157. Epub 2012 Oct 16.

DOI:10.1038/embor.2012.157
PMID:23070367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3512402/
Abstract

Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation.

摘要

基因复制会刺激进化创新，因为产生的同源基因会发生突变，导致亚功能化或新功能化。对酿酒酵母同源基因的全面计算机分析表明，细胞表面和端粒附近基因的重复也会发生异位重组，从而产生新的嵌合等位基因。在细胞表面基因 FLO（絮凝）家族中模拟这种基因间重组事件表明，嵌合 FLO 等位基因比亲本基因具有不同的粘附表型。我们的结果表明，同源基因之间的基因间重组可以产生大量新的等位基因，从而为进化适应和创新提供了原材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/8bc8da7afbca/embor2012157f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/0ceff390a76e/embor2012157f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/5f3b760c5c58/embor2012157f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/8bc8da7afbca/embor2012157f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/0ceff390a76e/embor2012157f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/5f3b760c5c58/embor2012157f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/3512402/8bc8da7afbca/embor2012157f3.jpg

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