Tu Yaqin, Chen Cai, Pan Junru, Xu Junfa, Zhou Zhi-Guang, Wang Cong-Yi
The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Int J Clin Exp Pathol. 2012;5(8):726-38. Epub 2012 Oct 1.
Accumulated evidence supports that the ubiquitin proteasome pathway (UPP) plays a crucial role in protein metabolism implicated in the regulation of many biological processes such as cell cycle control, DNA damage response, apoptosis, and so on. Therefore, alterations for the ubiquitin proteasome signaling or functional impairments for the ubiquitin proteasome components are involved in the etiology of many diseases, particularly in cancer development. In this minireview, we first give a brief outline for the ubiquitin proteasome pathway, we then discuss with focus for the ubiquitin proteasome pathway in the regulation of cell cycle control and DNA damage response, the relevance for the altered regulation of these signaling pathways in tumorigenesis is also reviewed. We finally assess and summarize the advancement for targeting the ubiquitin proteasome pathway in cancer therapy. A better understanding of the biological functions underlying ubiquitin regulatory mechanisms would provide us a wider prospective on cancer treatment.
越来越多的证据表明，泛素蛋白酶体途径（UPP）在蛋白质代谢中起着关键作用，这涉及到许多生物过程的调控，如细胞周期控制、DNA损伤反应、细胞凋亡等。因此，泛素蛋白酶体信号的改变或泛素蛋白酶体成分的功能受损与许多疾病的病因有关，尤其是在癌症发展过程中。在这篇综述中，我们首先简要概述泛素蛋白酶体途径，然后重点讨论泛素蛋白酶体途径在细胞周期控制和DNA损伤反应调控中的作用，还将综述这些信号通路调节改变与肿瘤发生的相关性。我们最后评估并总结了靶向泛素蛋白酶体途径在癌症治疗方面的进展。更好地理解泛素调节机制背后的生物学功能将为我们提供更广阔的癌症治疗前景。
