ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA, Australia.
Plant Signal Behav. 2012 Dec;7(12):1594-7. doi: 10.4161/psb.22250. Epub 2012 Oct 16.
The TIM17:23 complex on the mitochondrial inner membrane is responsible for import of the majority of mitochondrial proteins in plants. In Arabidopsis, Tim17 and Tim23 belong to a large gene family consisting of 16 members termed the Preprotein and Amino acid transporters (PRAT). Recently, two members of this protein family, Tim23-2 and the Complex I subunit B14.7, have been shown to assemble into both Complex I of the respiratory chain and the TIM17:23 complex (Wang et al., 2012), adding to other examples of links between respiratory and protein import complexes. These associations provide a mechanism to coordinate mitochondrial activity and biogenesis.
线粒体内膜上的 TIM17:23 复合物负责植物中大多数线粒体蛋白的输入。在拟南芥中，Tim17 和 Tim23 属于一个由 16 个成员组成的大型基因家族，称为前体蛋白和氨基酸转运蛋白（PRAT）。最近，该蛋白家族的两个成员，Tim23-2 和复合体 I 亚基 B14.7，已被证明可以组装到呼吸链的复合体 I 和 TIM17:23 复合物中（Wang 等人，2012 年），这增加了呼吸和蛋白输入复合物之间联系的其他例子。这些关联提供了协调线粒体活性和生物发生的机制。
