章鱼周边簇平均敏感度与使用 RTVue 光学相干断层扫描仪和扫描激光偏振仪测量的扇形视网膜神经纤维层厚度之间的结构-功能关系。

Structure-function relationship between the octopus perimeter cluster mean sensitivity and sector retinal nerve fiber layer thickness measured with the RTVue optical coherence tomography and scanning laser polarimetry.

机构信息

*Department of Ophthalmology †Cardiovascular Center, Semmelweis University, Budapest, Hungary.

出版信息

J Glaucoma. 2014 Jan;23(1):11-8. doi: 10.1097/IJG.0b013e318264cda2.

DOI:10.1097/IJG.0b013e318264cda2

PMID:22955015

Abstract

PURPOSE

To determine structure-function relationship between each of 16 Octopus perimeter G2 program clusters and the corresponding 16 peripapillary sector retinal nerve fiber layer thickness (RNFLT) values measured with the RTVue-100 Fourier-domain optical coherence tomography (RTVue OCT) and scanning laser polarimetry with variable corneal compensation (GDx-VCC) and enhanced corneal compensation (GDx-ECC) corneal compensation.

METHODS

One eye of 110 white patients (15 healthy, 20 ocular hypertensive, and 75 glaucoma eyes) were investigated. The Akaike information criterion and the F test were used to identify the best fitting model.

RESULTS

Parabolic relationship with logarithmic cluster mean sensitivity and linear sector RNFLT values provided the best fit. For RTVue OCT, significant (P<0.0001) coefficients of determination (R) were found for all 16 RNFLT sectors. The R values were highest for the temporal, superotemporal, and inferotemporal RNFLT sectors (0.4483 to 0.5186). For GDx-VCC/ECC, significant (P<0.01) parabolic relationship was seen for all but the temporal and nasal RNFLT sectors. The overall highest R value (0.6943) was found for a superotemporal RNFLT sector with GDx-ECC. For some RNFLT sectors, the goodness of fit differed significantly between the imaging methods. Structure-function relationship was similar for the total population and the glaucoma subgroup, whereas no relationship (P>0.05) was found for the control eyes.

CONCLUSIONS

Mean sensitivity of the Octopus visual field clusters showed significant parabolic relationship with the corresponding peripapillary RNFLT sectors. The relationship was more general with the RTVue OCT than GDx-VCC or GDx-ECC. The results show that visual field clusters of the Octopus G program can be applied for detailed structure-function research.

摘要

目的

确定 16 个章鱼周边 G2 程序簇中的每一个与 16 个对应视盘周围神经纤维层厚度（RNFLT）值之间的结构-功能关系，这些值是用 RTVue-100 傅里叶域光学相干断层扫描（RTVue OCT）和带有可变角膜补偿（GDx-VCC）和增强角膜补偿（GDx-ECC）的扫描激光偏振测量法测量的。

方法

对 110 名白人患者（15 名健康，20 名眼高压，75 名青光眼）的一只眼进行了研究。采用赤池信息量准则和 F 检验来确定最佳拟合模型。

结果

对数簇平均敏感值与线性扇形 RNFLT 值之间的抛物线关系提供了最佳拟合。对于 RTVue OCT，所有 16 个 RNFLT 扇形均发现具有显著意义（P<0.0001）的决定系数（R）。时间、上颞和下颞 RNFLT 扇区的 R 值最高（0.4483 至 0.5186）。对于 GDx-VCC/ECC，除了时间和鼻 RNFLT 扇区外，所有扇区均观察到显著的抛物线关系。使用 GDx-ECC 时，上颞部 RNFLT 扇区的总体最高 R 值（0.6943）。对于一些 RNFLT 扇区，两种成像方法的拟合优度差异显著。在总人群和青光眼亚组中，结构-功能关系相似，而在对照组中则没有发现相关性（P>0.05）。