柔红霉素糖组分柔红糖胺的绝对构型无疑是2,3,6-三脱氧-3-C-甲基-3-硝基-L-核糖己吡喃糖。
The absolute configuration of decilonitrose, a sugar component of decilorubicin, is undoubtedly 2,3,6-trideoxy-3-C-methyl-3-nitro-L-ribo-hexopyranose.
作者信息
Nishimura Y, Ishii K, Kondo S
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1990 Jan;43(1):54-61. doi: 10.7164/antibiotics.43.54.
PMID:2307630
Abstract
The absolute structure of decilonitrose, a sugar component of an antitumor antibiotic decilorubicin was decided to be 2,3,6-trideoxy-3-C-methyl-3-nitro-L-ribo-hexopyranose by synthesis of its methyl beta-glycoside starting from L-rhamnose through the 3-ulose. In the synthetic route, any configurational ambiguities do not exist.
摘要
抗肿瘤抗生素柔红霉素的糖组分去氧糖胺的绝对结构，通过从L-鼠李糖经3-酮糖出发合成其β-甲基糖苷，确定为2,3,6-三脱氧-3-C-甲基-3-硝基-L-核糖己吡喃糖。在合成路线中，不存在任何构型上的不确定性。
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