新型抗真菌抗生素贝纳霉素A和B的结构

The structures of new antifungal antibiotics, benanomicins A and B.

作者信息

Gomi S, Sezaki M, Kondo S, Hara T, Naganawa H, Takeuchi T

机构信息

Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.

出版信息

J Antibiot (Tokyo). 1988 Aug;41(8):1019-28. doi: 10.7164/antibiotics.41.1019.

DOI:10.7164/antibiotics.41.1019

PMID:3170340

Abstract

Structures of new antifungal antibiotics, benanomicins A and B were determined to be N-[[5-[6-deoxy-3-O-(beta-D-xylopyranosyl)-beta-D-galactopyranosyloxy+ ++ ]-5, 6-dihydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo++ + [a]naphthacen-2-yl]carbonyl]-D-alanine and N-[[5-[4-amino-4,6-dideoxy-3-O-(beta-D-xylopyranosyl)-beta-D- galactopyranosyloxy]-5,6-dihydro-1,6,9,14-tetrahydroxy-11-methoxy- 3-methyl-8,13-dioxobenzo[a]naphthacen-2-yl]carbonyl]-D-al ani ne, respectively, by spectral analyses and chemical degradation studies.

摘要

通过光谱分析和化学降解研究确定，新型抗真菌抗生素贝纳霉素A和B的结构分别为N-[[5-[6-脱氧-3-O-(β-D-吡喃木糖基)-β-D-吡喃半乳糖氧基]-5,6-二氢-1,6,9,14-四羟基-11-甲氧基-3-甲基-8,13-二氧苯并[a]萘并[2,1-b]菲-2-基]羰基]-D-丙氨酸和N-[[5-[4-氨基-4,6-二脱氧-3-O-(β-D-吡喃木糖基)-β-D-吡喃半乳糖氧基]-5,6-二氢-1,6,9,14-四羟基-11-甲氧基-3-甲基-8,13-二氧苯并[a]萘并[2,1-b]菲-2-基]羰基]-D-丙氨酸。