维里普拉宁A，诺加霉素类的一种新型蒽环类抗生素。I. 分离、表征、降解反应及生物学特性。

Viriplanin A, a new anthracycline antibiotic of the nogalamycin group. I. Isolation, characterization, degradation reactions and biological properties.

作者信息

Hütter K, Baader E, Frobel K, Zeeck A, Bauer K, Gau W, Kurz J, Schröder T, Wünsche C, Karl W

出版信息

J Antibiot (Tokyo). 1986 Sep;39(9):1193-204. doi: 10.7164/antibiotics.39.1193.

DOI:10.7164/antibiotics.39.1193

Abstract

Viriplanin A, a new anthracycline antibiotic produced by Ampullariella regularis strain SE 47, was isolated from a raw product that demonstrated activity against Herpes simplex viruses. Based on spectroscopic data, the structure of the aglycone, viriplanol, was determined, and the antibiotic was found to contain the sugar moieties 2-deoxy-L-fucose, 4-O-mesaconoyl-L-diginose and decilonitrose. In solution viriplanin A is very unstable to light. The antibiotic belongs to the nogalamycin group and is related to arugomycin and decilorubicin.

摘要

维里普拉宁A是由规则瓶霉菌株SE 47产生的一种新的蒽环类抗生素，从一种对单纯疱疹病毒具有活性的粗产物中分离得到。基于光谱数据确定了苷元维里普拉醇的结构，发现该抗生素含有糖部分2-脱氧-L-岩藻糖、4-O-中康酰-L-洋地黄糖和去氧夹竹桃糖。在溶液中，维里普拉宁A对光非常不稳定。该抗生素属于诺加霉素类，与阿柔比星和去甲柔红霉素有关。