Miu Smaranda Stefana, Ancuţa Codrina, Belibou Iulia Codruţa, Macovei Luana, Chirieac Rodica
Facultatea de Medicină, Universităţii de Medicină si Farmacie "Grigore T. Popa", Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2012 Jan-Mar;116(1):50-5.
To evaluate health-related quality of life and disability in psoriatic arthritis (PsA) and to perform a complex biomechanical gait analysis in patients with PsA versus healthy controls.
Preliminary prospective study on 33 consecutive PsA (2006 CASPAR criteria), with active multiple joint involvement disease. Assessments were done according to a predefined protocol and included: rheumatology-clinical evaluation and activity scores, dermatology- Psoriasis Area and Severity Index, PASI-score; functional disability- Health Assessment Questionnaire, HAQ, quality of life score- Short Form36, SF36; biomechanical gait analysis- tridimensional VICON MX optical motion capture system in PsA versus 33 age- and sex-matched healthy controls. SPSS, EPI-INFO and MS EXCEL were used for statistical analysis.
While the majority of PsA patients experienced a moderate impact on the quality of life as assessed by SF36 analysis, severe disease had major impact on their physical and emotional health status. The VICON gait analysis proved the statistical significant change (p < 0.05) on several gait parameters as compared to controls, including: decreased range of motion for flexion/extension of the lower limbs joins and lower cadence, decreased walking speed and step length. Statistically si gnificant correlations (Spearman, p < 0.05) between changes in PsA gait parameters and SF36 results, but no association with HAQ (p > 0.05) has been reported.
The PsA burden is related to both quality of life and functional impairment. Severe changes in gait parameters are essentially reflected in SF36 analysis.
评估银屑病关节炎（PsA）患者与健康对照者的健康相关生活质量和残疾状况，并对PsA患者进行复杂的生物力学步态分析。
对33例符合2006年CASPAR标准且有多关节受累的活动性PsA患者进行初步前瞻性研究。评估按照预先定义的方案进行，包括：风湿病临床评估和活动评分、皮肤病学——银屑病面积和严重程度指数（PASI评分）；功能残疾——健康评估问卷（HAQ）、生活质量评分——简明健康调查问卷（SF36）；生物力学步态分析——使用三维VICON MX光学运动捕捉系统对PsA患者与33名年龄和性别匹配的健康对照者进行分析。使用SPSS、EPI-INFO和MS EXCEL进行统计分析。
通过SF36分析评估，大多数PsA患者的生活质量受到中度影响，而严重疾病对其身体和心理健康状况有重大影响。与对照组相比，VICON步态分析证明了几个步态参数有统计学显著变化（p<0.05），包括：下肢关节屈伸活动范围减小、步频降低、步行速度和步长减小。据报道，PsA步态参数变化与SF36结果之间存在统计学显著相关性（Spearman相关性，p<0.05），但与HAQ无关联（p>0.05）。
PsA的负担与生活质量和功能损害均相关。步态参数的严重变化在SF36分析中基本得到体现。
