用于癌症免疫治疗的免疫细胞膜包被纳米颗粒
Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy.
作者信息
Gong Ping, Wang Yifan, Zhang Pengfei, Yang Zhaogang, Deng Weiye, Sun Zhihong, Yang Mingming, Li Xuefeng, Ma Gongcheng, Deng Guanjun, Dong Shiyan, Cai Lintao, Jiang Wen
机构信息
Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2280 Inwood Road, Dallas, TX 75235, USA.
出版信息
Cancers (Basel). 2020 Dec 30;13(1):77. doi: 10.3390/cancers13010077.
Despite the advances in surface bioconjugation of synthetic nanoparticles for targeted drug delivery, simple biological functionalization is still insufficient to replicate complex intercellular interactions naturally. Therefore, these foreign nanoparticles are inevitably exposed to the immune system, which results in phagocytosis by the reticuloendothelial system and thus, loss of their biological significance. Immunocyte membranes play a key role in intercellular interactions, and can protect foreign nanomaterials as a natural barrier. Therefore, biomimetic nanotechnology based on cell membranes has developed rapidly in recent years. This paper summarizes the development of immunocyte membrane-coated nanoparticles in the immunotherapy of tumors. We will introduce several immunocyte membrane-coated nanocarriers and review the challenges to their large-scale preparation and application.
尽管在用于靶向药物递送的合成纳米颗粒的表面生物共轭方面取得了进展，但简单的生物功能化仍不足以自然地复制复杂的细胞间相互作用。因此，这些外来纳米颗粒不可避免地会暴露于免疫系统，从而导致被网状内皮系统吞噬，进而丧失其生物学意义。免疫细胞膜在细胞间相互作用中起关键作用，并且可以作为天然屏障保护外来纳米材料。因此，基于细胞膜的仿生纳米技术近年来发展迅速。本文总结了免疫细胞膜包覆纳米颗粒在肿瘤免疫治疗中的发展。我们将介绍几种免疫细胞膜包覆的纳米载体，并综述其大规模制备和应用面临的挑战。
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