Celica, Biomedical Center, Technology Park, Ljubljana, Slovenia.
Phytomedicine. 2012 Nov 15;19(14):1270-84. doi: 10.1016/j.phymed.2012.09.007. Epub 2012 Oct 16.
Over more than 20 years, the endophytic fungi have been explored as "biofactories" of novel bioactive substances, and they have not disappointed. Among the extracts and pure substances obtained from the culture broths or fungal biomass, some have exerted antibacterial activity ranging from moderate to powerful when tested on the bacterial strains resistant to the antibiotics currently in use. In this article we review the accumulated data on endophytic fungi isolated from plants that produce metabolites with antibacterial activity against human pathogenic bacteria.
在 20 多年的时间里，内生真菌一直被探索作为新型生物活性物质的“生物工厂”，它们并没有让人失望。从培养物或真菌生物量中获得的提取物和纯物质中，一些物质在测试对目前使用的抗生素具有抗性的细菌菌株时，表现出从中等到强大的抗菌活性。在本文中，我们综述了从具有抗人体病原菌活性代谢产物的植物中分离出的内生真菌的累积数据。
