INQUINOA-CONICET, Ayacucho 491, Tucumán 4000, Argentina.
J Nat Prod. 2011 Apr 25;74(4):574-9. doi: 10.1021/np100472d. Epub 2011 Mar 8.
Four fusicoccane-type diterpenoids (1-4), including the new 1 and 2; four pinguisane-type sesquiterpenoids (5-8); and two aromadendrane-type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%), 9 (45 and 41%), and 10 (48 and 37%) at 50 and 5 μg/mL, respectively. Compounds 3, 9, and 10 also produced a slight decrease in bacterial growth and interfere with the process of quorum sensing at the same doses.
从阿根廷特有地钱 Porella chilensis 的一个采集品中分离得到四个 Fus coccan 型二萜（1-4），包括新化合物 1 和 2；四个 Pinguisane 型倍半萜（5-8）；和两个 Aromadendrane 型倍半萜（9 和 10）。化合物 3（53% 和 47%）、9（45% 和 41%）和 10（48% 和 37%）在 50 和 5 μg/mL 时分别抑制人类病原体铜绿假单胞菌的生物膜形成。在相同剂量下，化合物 3、9 和 10 还能轻微抑制细菌生长并干扰群体感应过程。
