FBK, Via Sommarive 18, 38123 Trento, Italy.
Langmuir. 2012 Nov 13;28(45):15900-6. doi: 10.1021/la303298u. Epub 2012 Oct 31.
Branched gold nanoparticles were grown on oxidized multiwalled carbon nanotubes by one-step reduction of gold chloride in water. The carbon nanotube/gold hybrids were used for the delivery of the anticancer drug doxorubicin hydrochloride into A549 lung cancer cell line. Doxorubicin (Dox) can be adsorbed in high quantity on both inner and outer surfaces of oxidized carbon nanotubes by π-π stacking interactions between doxorubicin aromatic groups and carbon nanotube (CNT) backbone. Carbon nanotube/gold hybrids display a broad absorption band in the red and near-infrared regions allowing their use for imaging applications. In vitro cellular tests showed that the nanostructures can efficiently transport and deliver doxorubicin inside the cells.
支化金纳米粒子通过一步还原水中的氯化金在氧化多壁碳纳米管上生长。将碳纳米管/金杂化物用于将盐酸阿霉素抗癌药物递送到 A549 肺癌细胞系中。通过阿霉素芳香基团与碳纳米管（CNT）主链之间的π-π堆积相互作用，阿霉素（Dox）可以大量吸附在氧化碳纳米管的内外表面上。碳纳米管/金杂化物在红色和近红外区域显示出宽的吸收带，允许它们用于成像应用。体外细胞试验表明，这些纳米结构可以有效地将阿霉素输送并递送到细胞内部。
