Barada Kassem, Abu Daya Hussein, Rostami Kamran, Catassi Carlo
Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Riad-El-Solh Beirut, Lebanon.
Gastrointest Endosc Clin N Am. 2012 Oct;22(4):773-96. doi: 10.1016/j.giec.2012.07.002. Epub 2012 Aug 24.
The prevalence of celiac disease (CD) in many developing countries is similar to that of developed areas, in both low- and high-risk groups. The disorder is underestimated because of lack of disease awareness. CD is strongly associated with HLA-DQ2 in developing countries. Clinical presentation may be characterized by chronic diarrhea, anemia, stunting and increased mortality. Few studies have addressed atypical or silent CD. Diagnosis is initially made by serologic tests and is confirmed by small intestinal biopsies. In developing countries the adherence to the treatment is still difficult because of poor availability of dedicated gluten-free food.
在许多发展中国家，无论是低风险组还是高风险组，乳糜泻（CD）的患病率与发达地区相似。由于对该疾病缺乏认识，这种病症被低估了。在发展中国家，CD与HLA-DQ2密切相关。临床表现可能以慢性腹泻、贫血、发育迟缓及死亡率增加为特征。很少有研究涉及非典型或隐匿性CD。诊断最初通过血清学检测进行，随后通过小肠活检加以证实。在发展中国家，由于专用无麸质食品供应不足，坚持治疗仍然困难。
