Laboratoire BIOGEP, Ecole Nationale Polytechnique, 10 Avenue Pasteur, El Harrach, Alger, Algeria.
Int J Biol Macromol. 2013 Jan;52:333-9. doi: 10.1016/j.ijbiomac.2012.10.009. Epub 2012 Oct 17.
In the present study, anticancer activities of chitin, chitosan and low molecular weight chitin were evaluated using a human tumour cell line, THP-1. A molecular weight-activity relationship and an electrostatic interaction-activity relationship were determined. The cytotoxic effects of chitin and derivatives were also evaluated using a normal human foetal lung fibroblastic cell line, MRC-5 and the specific cytotoxicity of chitin and derivatives to tumour cell lines was demonstrated. The high antitumour effect of low molecular weight of chitin was established.
在本研究中，使用人类肿瘤细胞系 THP-1 评估了壳聚糖、低分子量壳聚糖的抗癌活性。确定了分子量-活性关系和静电相互作用-活性关系。还使用正常的人胎肺成纤维细胞系 MRC-5 评估了壳聚糖及其衍生物的细胞毒性作用，并证明了壳聚糖及其衍生物对肿瘤细胞系的特异性细胞毒性。建立了低分子量壳聚糖的高抗肿瘤作用。
