参与自然杀伤细胞发育和功能调控的转录因子：最新进展。
Transcription factors involved in the regulation of natural killer cell development and function: an update.
机构信息
Anthony Nolan Research Institute London, UK ; University College London London, UK.
出版信息
Front Immunol. 2012 Oct 15;3:319. doi: 10.3389/fimmu.2012.00319. eCollection 2012.
Natural killer (NK) cells belong to the innate immune system and are key effectors in the immune response against cancer and infection. Recent studies have contributed to the knowledge of events controlling NK cell fate. The use of knockout mice has enabled the discovery of key transcription factors (TFs) essential for NK cell development and function. Yet, unwrapping the downstream targets of these TFs and their influence on NK cells remains a challenge. In this review, we discuss the latest TFs described to be involved in the regulation of NK cell development and maturation.
自然杀伤 (NK) 细胞属于先天免疫系统，是针对癌症和感染的免疫反应中的关键效应物。最近的研究有助于了解控制 NK 细胞命运的事件。使用基因敲除小鼠使发现对 NK 细胞发育和功能至关重要的关键转录因子 (TF) 成为可能。然而，揭示这些 TF 的下游靶标及其对 NK 细胞的影响仍然是一个挑战。在这篇综述中，我们讨论了最新描述的参与 NK 细胞发育和成熟调控的 TF。
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