人类对真菌感染的遗传易感性。
Genetic Susceptibility to Fungal Infections in Humans.
作者信息
Lionakis Michail S
机构信息
Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
出版信息
Curr Fungal Infect Rep. 2012 Mar 1;6(1):11-22. doi: 10.1007/s12281-011-0076-4. Epub 2011 Dec 15.
Abstract
Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that typically involve mucocutaneous surfaces. Hence, when persistent or recurrent mucocutaneous infections (chronic mucocutaneous candidiasis [CMC]) or invasive fungal infections (IFIs) develop in a "normal" host, they are indicative of genetic defects causing innate or adaptive immune dysfunction. In this review, recent developments concerning genetic and immunologic factors that affect the risk for IFIs and CMC are critically discussed.
摘要
大多数人类真菌感染发生在医源性免疫抑制或HIV感染的情况下。在没有这些因素的情况下，真菌会引起轻度、自限性感染，通常累及皮肤黏膜表面。因此，当“正常”宿主发生持续性或复发性皮肤黏膜感染（慢性皮肤黏膜念珠菌病[CMC]）或侵袭性真菌感染（IFI）时，它们表明存在导致先天性或适应性免疫功能障碍的基因缺陷。在这篇综述中，我们将批判性地讨论影响IFI和CMC风险的遗传和免疫因素的最新进展。
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