Fegerl Gundula, Marosi Christine
Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna;
Rare Tumors. 2012 Jun 26;4(3):e42. doi: 10.4081/rt.2012.e42. Epub 2012 Sep 6.
We report on a 59-year old woman with three huge intrathoracal masses that were accidentally diagnosed when she consulted a physician for upper abdominal discomfort. A biopsy revealed that they were metastases of a coccygeal myxopapillary ependymoma, resected 20 years before. As neither resection, debulking, nor radiation therapy were considered to be indicated, systemic therapy with temozolomide was started. At the first evaluation after four months, the metastases had progressed. Imatinib delayed the progression, but had to be stopped after six months because of critical increased pleural effusion. Using the multikinase inhibitor sorafenib, the disease was stabilized and an acceptable quality of life could be obtained for one year.
我们报告了一名59岁女性，她有三个巨大的胸腔内肿块，这些肿块是在她因上腹部不适咨询医生时意外诊断出来的。活检显示它们是20年前切除的尾骨黏液乳头型室管膜瘤的转移灶。由于认为既不适合进行切除、减瘤手术，也不适合进行放射治疗，于是开始使用替莫唑胺进行全身治疗。在四个月后的首次评估中，转移灶进展了。伊马替尼延缓了病情进展，但由于严重的胸腔积液增加，六个月后不得不停药。使用多激酶抑制剂索拉非尼，病情得到稳定，并且在一年的时间里获得了可接受的生活质量。
