NAICONS Scrl , Via Fantoli 16/15, 20138 Milano, Italy.
J Nat Prod. 2012 Nov 26;75(11):1991-3. doi: 10.1021/np300470f. Epub 2012 Oct 22.
Examination of the metabolites produced by an Actinospica strain led to the identification of 6-hydroxychrolactomycin (compound 1), which is produced along with minor amounts of chrolactomycin (compound 2). The structure of 1 was established on the basis of extensive spectroscopic analysis, including one- and two-dimensional NMR. Compound 1 showed antimicrobial activity against Gram-positive bacteria, although it was generally less active than 2.
对一株 Actinospica 菌株产生的代谢产物进行研究，鉴定出 6-羟基氯罗他霉素（化合物 1），其与少量氯罗他霉素（化合物 2）同时产生。通过包括一维和二维 NMR 在内的广泛光谱分析，确定了 1 的结构。化合物 1 对革兰氏阳性菌表现出抗菌活性，但其活性通常低于 2。
