灰黄霉素 F 和 G，来自锡矿尾矿衍生的嗜堿放线菌属的螺-萘醌。
Griseusins F and G, spiro-naphthoquinones from a tin mine tailings-derived alkalophilic Nocardiopsis species.
机构信息
Key Laboratory for Microbial Resources, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University , Kunming, 650091, People's Republic of China.
出版信息
J Nat Prod. 2012 Nov 26;75(11):1994-8. doi: 10.1021/np3004936. Epub 2012 Oct 24.
Griseusins F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C23 polyketide skeleton, were isolated from a Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiopsis sp. YIM DT266. Their complete structure assignments with the absolute stereochemistry were elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, and CD spectroscopic analysis. Compounds 1 and 2 exhibited strong cytotoxicity (IC50 0.37-0.82 μM) and antibacterial activity (MIC 0.80-1.65 μg/mL) against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
灰绿菌素 F（1）和 G（2）是两种具有先前未描述的 C23 聚酮骨架的 2a-氢-8a-（2-氧代丙基）取代的螺-萘醌，从云南锡矿尾矿来源的嗜碱性放线菌 Nocardiopsis sp. YIM DT266 中分离得到。通过光谱数据、X 射线晶体衍射、旋光度计算和 CD 光谱分析，确定了它们的完整结构，并确定了绝对立体化学。化合物 1 和 2 表现出强烈的细胞毒性（IC50 为 0.37-0.82 μM）和抗菌活性（MIC 为 0.80-1.65 μg/mL），对革兰氏阳性菌，包括体外耐甲氧西林金黄色葡萄球菌（MRSA）具有活性。
Zotero 插件