Moa G, Zetterström H
Department of Anaesthesia and Intensive Care, Ostersund Hospital, Sweden.
Acta Anaesthesiol Scand. 1990 Jan;34(1):68-71. doi: 10.1111/j.1399-6576.1990.tb03044.x.
Buprenorphine and pethidine as postoperative analgesics were compared in 96 women having gynaecological operations by lower laparotomy. A fixed dose of the respective drug was given in a double-blind and double-dummy manner, initially intramuscularly and thereafter by sublingual buprenorphine (0.4 mg) or intramuscular pethidine (75 mg) at the request of the patient during the first 24 h postoperatively. Patients receiving buprenorphine had longer dose intervals and thus needed fewer doses. The analgesic effect, as assessed by a visual analog scale, was similar with both drugs. There were no significant differences between the groups regarding respiratory depression and nausea. It appears that sublingual buprenorphine is as effective and safe as intramuscular pethidine in the postoperative period.
对96例行下腹部剖腹术的妇科手术女性患者，比较了丁丙诺啡和哌替啶作为术后镇痛药的效果。以双盲双模拟方式给予固定剂量的相应药物，最初为肌内注射，术后24小时内根据患者需求，随后给予舌下含服丁丙诺啡（0.4毫克）或肌内注射哌替啶（75毫克）。接受丁丙诺啡的患者给药间隔时间更长，因此所需剂量更少。通过视觉模拟评分评估，两种药物的镇痛效果相似。两组在呼吸抑制和恶心方面无显著差异。术后，舌下含服丁丙诺啡似乎与肌内注射哌替啶一样有效且安全。
