Department of Neurosurgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110003, China.
Mol Biol Rep. 2013 Jan;40(1):567-72. doi: 10.1007/s11033-012-2093-y. Epub 2012 Oct 25.
Previous studies show that X-ray cross-complementing group 1 (XRCC 1) Arg399Gln may result in variations in repair efficiency of DNA damage, and this repair deficit may eventually cause individual susceptibility to glioma. However, published data regarding the association between XRCC 1 Arg399Gln polymorphism and glioma risk was contradictory. The aim of this study was to derive a more precise estimation of the association of XRCC 1 Arg399Gln polymorphism with glioma risk by performing a meta-analysis of eligible studies. Odds ratios (ORs) and 95 % confidence intervals (95 %CIs) were used to assess the strength of the association. We performed a meta-analysis of eleven published studies that included 2,808 glioma cases and 3,114 controls. Overall, there was a significant association between XRCC1 Arg399Gln polymorphism and glioma risk in two genetic models (for ArgGln vs ArgArg: OR = 1.30, 95 % CI 1.01-1.68; for GlnGln/ArgGln vs ArgArg: OR = 1.28, 95 % CI 1.01-1.62). In the stratified analysis by ethnicity, the XRCC1 Arg399Gln polymorphism had a higher risk of glioma development among Asians (for Gln vs Arg: OR = 1.34, 95 % CI 1.12-1.61; for GlnGln vs ArgArg: OR = 1.72, 95 % CI 1.18-2.51; for ArgGln vs ArgArg: OR = 1.31, 95 % CI 1.01-1.71; for GlnGln/ArgGln vs ArgArg: OR = 1.41, 95 % CI 1.10-1.80; for GlnGln vs ArgArg/ArgGln: OR = 1.48, 95 % CI 1.05-2.09)., but not among Caucasians. In conclusion, the results suggest that the XRCC 1 Arg399Gln polymorphism may contribute to the susceptibility of glioma in Asians.
先前的研究表明，X 射线交叉互补群 1（XRCC1）Arg399Gln 可能导致 DNA 损伤修复效率的变化，而这种修复缺陷最终可能导致个体易患神经胶质瘤。然而，关于 XRCC1 Arg399Gln 多态性与神经胶质瘤风险之间的关联，已发表的数据存在矛盾。本研究旨在通过对合格研究进行荟萃分析，得出更精确的 XRCC1 Arg399Gln 多态性与神经胶质瘤风险关联的估计。比值比（OR）和 95%置信区间（95%CI）用于评估关联的强度。我们对包括 2808 例神经胶质瘤病例和 3114 例对照的 11 项已发表研究进行了荟萃分析。总体而言，在两种遗传模型中，XRCC1 Arg399Gln 多态性与神经胶质瘤风险之间存在显著关联（ArgGln 与 ArgArg：OR=1.30，95%CI 1.01-1.68；GlnGln/ArgGln 与 ArgArg：OR=1.28，95%CI 1.01-1.62）。按种族进行分层分析时，XRCC1 Arg399Gln 多态性增加了亚洲人神经胶质瘤发病的风险（Gln 与 Arg：OR=1.34，95%CI 1.12-1.61；GlnGln 与 ArgArg：OR=1.72，95%CI 1.18-2.51；ArgGln 与 ArgArg：OR=1.31，95%CI 1.01-1.71；GlnGln/ArgGln 与 ArgArg：OR=1.41，95%CI 1.10-1.80；GlnGln 与 ArgArg/ArgGln：OR=1.48，95%CI 1.05-2.09）。但在白种人中并非如此。总之，结果表明 XRCC1 Arg399Gln 多态性可能导致亚洲人易患神经胶质瘤。
