Li Yi, Huang Yi, Cao Yu-Shu, Zeng Jia, Tong Wan-Ning, Xu Shi-Lin, Zhuo An-Shan
Department of Respiratory Medicine, the 411th Hospital of PLA, Shanghai, 200081, China.
Tumour Biol. 2013 Dec;34(6):3681-5. doi: 10.1007/s13277-013-0950-5. Epub 2013 Jul 25.
X-ray repair cross-complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base excision repair and plays an important role in the maintenance of genomic integrity. Polymorphisms in XRCC1 may alter the function and repair capacity of XRCC1 protein which further results in the genetic instability and lung carcinogenesis. Previous studies investigating the relationship between XRCC1 Arg399Gln polymorphism and lung cancer risk in Chinese yielded contradictory results. A meta-analysis was performed to clarify the effect of XRCC1 Arg399Gln polymorphism on lung cancer. The association was assessed by calculating the pooled odds ratio (OR) with 95% confidence intervals (95%CI). Nineteen studies with a total of 12,835 participants were included into this meta-analysis. Overall, there was an obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer under three genetic models (Gln vs. Arg: OR = 1.13, 95%CI 1.01-1.25, P = 0.029; GlnGln vs. ArArg: OR = 1.41, 95%CI 1.07-1.84, P = 0.013; GlnGln vs. ArArg/ArgGln: OR = 1.37, 95%CI 1.07-1.76, P = 0.013). Meta-analysis of 18 studies with high quality also found that there was an obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer under three genetic models. There was no obvious risk of bias in the meta-analysis. Data from the current meta-analysis support the obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer in Chinese.
X射线修复交叉互补基因1（XRCC1）是参与碱基切除修复的主要DNA修复蛋白之一，在维持基因组完整性方面发挥着重要作用。XRCC1基因多态性可能会改变XRCC1蛋白的功能和修复能力，进而导致基因不稳定和肺癌发生。以往关于XRCC1基因第399位密码子精氨酸/谷氨酰胺（Arg399Gln）多态性与中国人群肺癌风险关系的研究结果相互矛盾。本研究进行荟萃分析以阐明XRCC1 Arg399Gln多态性对肺癌的影响。通过计算合并比值比（OR）及95%置信区间（95%CI）来评估两者之间的关联。本荟萃分析共纳入19项研究，总计12835名参与者。总体而言，在三种遗传模型下，XRCC1 Arg399Gln多态性与肺癌风险增加之间存在明显关联（谷氨酰胺与精氨酸比较：OR = 1.13，95%CI 1.01 - 1.25，P = 0.029；谷氨酰胺纯合子与精氨酸纯合子比较：OR = 1.41，95%CI 1.07 - 1.84，P = 0.013；谷氨酰胺纯合子与精氨酸纯合子/精氨酸谷氨酰胺杂合子比较：OR = 1.37，95%CI 1.07 - 1.76，P = 0.013）。对18项高质量研究的荟萃分析也发现，在三种遗传模型下，XRCC1 Arg399Gln多态性与肺癌风险增加之间存在明显关联。本荟萃分析不存在明显的偏倚风险。当前荟萃分析的数据支持XRCC1 Arg399Gln多态性与中国人群肺癌风险增加之间存在明显关联。
