Department of Biotechnology & Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, HP, India.
Food Funct. 2013 Feb;4(2):240-8. doi: 10.1039/c2fo30125c.
We developed a novel sea buckthorn wine containing significant in vitro free radical-scavenging activity. High-performance liquid chromatographic analysis of the sea buckthorn wine revealed that it contains high rutin, myricetin and quercetin levels compared to Cabernet Shiraz wine. In this study, we evaluated the protective effects of sea buckthorn wine against phorone-induced oxidative stress and high-cholesterol diet induced hypercholesterolemia in male LACA mice. Oral administration of sea buckthorn wine increased the redox ratio accompanied by reduction of oxidized glutathione levels leading to attenuation of phorone-induced oxidative stress. Furthermore, the sea buckthorn wine supplementation reduced hepatic lipid peroxidation and increased the superoxide dismutase activity indicating improved resistance to oxidative stress. In addition, high-cholesterol-fed mice administered with sea buckthorn wine exhibited a 197% increase in the HDL-C/LDL-C ratio compared to high-cholesterol diet treated mice. These studies provide important evidence that sea buckthorn wine exerts protective effects against oxidative stress and hypercholesterolemia.
我们开发了一种新型沙棘酒，具有显著的体外自由基清除活性。高效液相色谱分析表明，与赤霞珠葡萄酒相比，沙棘酒含有高浓度的芦丁、杨梅素和槲皮素。在这项研究中，我们评估了沙棘酒对雄性 LACA 小鼠诱导氧化应激和高胆固醇饮食诱导高胆固醇血症的保护作用。沙棘酒的口服给药增加了氧化还原比，同时降低了氧化型谷胱甘肽水平，从而减轻了诱导的氧化应激。此外，沙棘酒的补充降低了肝脂质过氧化作用，并增加了超氧化物歧化酶活性，表明对氧化应激的抵抗力增强。此外，与高胆固醇饮食组相比，给予沙棘酒的高胆固醇饮食组的 HDL-C/LDL-C 比值增加了 197%。这些研究提供了重要证据，表明沙棘酒对氧化应激和高胆固醇血症具有保护作用。
