Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, 1150 W Medical Center Drive, 6301 MSRB III SPC 5642, Ann Arbor, MI, 48109, USA.
J Pathol. 2013 Jan;229(2):141-4. doi: 10.1002/path.4126.
Estimates from various disease-specific registries suggest that chronic inflammatory and fibrotic disorders affect a large proportion of the world's population, yet therapies for these conditions are largely ineffective. Recent advances in our collective understanding of mechanisms underlying both physiological and pathological repair of tissue injury are informing new clinical approaches to deal with various human inflammatory and fibrotic diseases. This 2013 Annual Review Issue of The Journal of Pathology offers an up-to-date glimpse of ongoing research in the fields of inflammation, wound healing, and tissue fibrosis, and highlights novel pathways and mechanisms that may be exploited to provide newer, more effective treatments to patients worldwide suffering from these conditions.
各种疾病特定登记处的估计表明，慢性炎症和纤维化疾病影响了世界上很大一部分人口，但这些疾病的治疗方法在很大程度上是无效的。我们对组织损伤的生理和病理修复机制的集体理解的最新进展，为应对各种人类炎症和纤维化疾病提供了新的临床方法。本期《病理学杂志》的年度综述专刊提供了对炎症、伤口愈合和组织纤维化领域正在进行的研究的最新了解，并强调了可能被利用为全球患有这些疾病的患者提供更新、更有效的治疗方法的新途径和新机制。
